Driving proteins off DNA using applied tension.
نویسندگان
چکیده
Proteins that bind DNA so as to reduce its end-to-end length can be dissociated by application of force. The thermodynamics of this process are discussed, with special attention to the case of histones bound to DNA (i.e., a string of nucleosomes, or chromatin fiber). The histone octamer is predicted to be driven off chromatin fiber for tensions >2 piconewtons.
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ورودعنوان ژورنال:
- Biophysical journal
دوره 73 4 شماره
صفحات -
تاریخ انتشار 1997